Yes, with these limitations: Tile must be installed per installation standards published in the most current TCNA Handbook, ANSI 108 specification. If the OSB is weather-beaten or delaminated, it must be properly overlaid with a cement backer unit or an additional layer of subfloor.
For sound reduction, crack isolation, waterproofing and vapor management. If using Mapeguard 2 for vapor management, do not use MAPEI SM Primer or MAPEI SM Primer Fast, instead use MAPEI HM Primer. BB Tape
Do not use on shower floors or in submerged applications or floors subject to standing water